Lymphatic endothelium in health and disease.
Identifieur interne : 006197 ( Main/Exploration ); précédent : 006196; suivant : 006198Lymphatic endothelium in health and disease.
Auteurs : Giorgia Jurisic [Suisse] ; Michael DetmarSource :
- Cell and tissue research [ 1432-0878 ] ; 2009.
Descripteurs français
- KwdFr :
- Absorption intestinale, Animaux, Antigènes de différenciation (métabolisme), Endothélium lymphatique (anatomopathologie), Endothélium lymphatique (métabolisme), Humains, Lymphoedème (anatomopathologie), Lymphoedème (métabolisme), Matières grasses alimentaires (métabolisme), Myocarde (anatomopathologie), Myocarde (métabolisme), Noeuds lymphatiques (anatomopathologie), Noeuds lymphatiques (métabolisme), Protéines et peptides de signalisation intercellulaire (métabolisme), Vaisseaux lymphatiques (anatomopathologie), Vaisseaux lymphatiques (métabolisme).
- MESH :
- anatomopathologie : Endothélium lymphatique, Lymphoedème, Myocarde, Noeuds lymphatiques, Vaisseaux lymphatiques.
- métabolisme : Antigènes de différenciation, Endothélium lymphatique, Lymphoedème, Matières grasses alimentaires, Myocarde, Noeuds lymphatiques, Protéines et peptides de signalisation intercellulaire, Vaisseaux lymphatiques.
- Absorption intestinale, Animaux, Humains.
English descriptors
- KwdEn :
- Animals, Antigens, Differentiation (metabolism), Dietary Fats (metabolism), Endothelium, Lymphatic (metabolism), Endothelium, Lymphatic (pathology), Humans, Intercellular Signaling Peptides and Proteins (metabolism), Intestinal Absorption, Lymph Nodes (metabolism), Lymph Nodes (pathology), Lymphatic Vessels (metabolism), Lymphatic Vessels (pathology), Lymphedema (metabolism), Lymphedema (pathology), Myocardium (metabolism), Myocardium (pathology).
- MESH :
- chemical , metabolism : Antigens, Differentiation, Dietary Fats, Intercellular Signaling Peptides and Proteins.
- metabolism : Endothelium, Lymphatic, Lymph Nodes, Lymphatic Vessels, Lymphedema, Myocardium.
- pathology : Endothelium, Lymphatic, Lymph Nodes, Lymphatic Vessels, Lymphedema, Myocardium.
- Animals, Humans, Intestinal Absorption.
Abstract
The lymphatic vascular system has an important role in the maintenance of tissue fluid pressure homeostasis, in the mediation of the afferent immune response via recruitment of antigen-presenting cells toward draining lymph nodes, and in the intestinal absorption of dietary lipids. Substantial progress in our understanding of the development and the molecular mechanisms controlling the lymphatic system has been made during the last few years, based on a recent wave of discoveries of lymphatic endothelial cell-specific markers and growth factors. This has also led to new insights into the role of lymphatic endothelium in a number of diseases, including primary and secondary lymphedemas. The emerging role of lymphatic endothelium in the context of inflammation indicates that therapeutics targeting the lymphatic vasculature might represent a new strategy for anti-inflammatory therapies.
DOI: 10.1007/s00441-008-0644-2
PubMed: 18648856
Affiliations:
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Le document en format XML
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first="Giorgia" last="Jurisic">Giorgia Jurisic</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Pharmaceutical Sciences, ETH Zurich, Wolfgang Pauli-Strasse 10, HCI H390, CH-8093 Zurich, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Institute of Pharmaceutical Sciences, ETH Zurich, Wolfgang Pauli-Strasse 10, HCI H390, CH-8093 Zurich</wicri:regionArea><wicri:noRegion>CH-8093 Zurich</wicri:noRegion></affiliation></author><author><name sortKey="Detmar, Michael" sort="Detmar, Michael" uniqKey="Detmar M" first="Michael" last="Detmar">Michael Detmar</name></author></analytic><series><title level="j">Cell and tissue research</title><idno type="eISSN">1432-0878</idno><imprint><date when="2009" type="published">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Antigens, Differentiation (metabolism)</term><term>Dietary Fats (metabolism)</term><term>Endothelium, Lymphatic (metabolism)</term><term>Endothelium, Lymphatic (pathology)</term><term>Humans</term><term>Intercellular Signaling Peptides and Proteins (metabolism)</term><term>Intestinal Absorption</term><term>Lymph Nodes (metabolism)</term><term>Lymph Nodes (pathology)</term><term>Lymphatic Vessels (metabolism)</term><term>Lymphatic Vessels (pathology)</term><term>Lymphedema (metabolism)</term><term>Lymphedema (pathology)</term><term>Myocardium (metabolism)</term><term>Myocardium (pathology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Absorption intestinale</term><term>Animaux</term><term>Antigènes de différenciation (métabolisme)</term><term>Endothélium lymphatique (anatomopathologie)</term><term>Endothélium lymphatique (métabolisme)</term><term>Humains</term><term>Lymphoedème (anatomopathologie)</term><term>Lymphoedème (métabolisme)</term><term>Matières grasses alimentaires (métabolisme)</term><term>Myocarde (anatomopathologie)</term><term>Myocarde (métabolisme)</term><term>Noeuds lymphatiques (anatomopathologie)</term><term>Noeuds lymphatiques (métabolisme)</term><term>Protéines et peptides de signalisation intercellulaire (métabolisme)</term><term>Vaisseaux lymphatiques (anatomopathologie)</term><term>Vaisseaux lymphatiques (métabolisme)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Antigens, Differentiation</term><term>Dietary Fats</term><term>Intercellular Signaling Peptides and Proteins</term></keywords><keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Endothélium lymphatique</term><term>Lymphoedème</term><term>Myocarde</term><term>Noeuds lymphatiques</term><term>Vaisseaux lymphatiques</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Endothelium, Lymphatic</term><term>Lymph Nodes</term><term>Lymphatic Vessels</term><term>Lymphedema</term><term>Myocardium</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Antigènes de différenciation</term><term>Endothélium lymphatique</term><term>Lymphoedème</term><term>Matières grasses alimentaires</term><term>Myocarde</term><term>Noeuds lymphatiques</term><term>Protéines et peptides de signalisation intercellulaire</term><term>Vaisseaux lymphatiques</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Endothelium, Lymphatic</term><term>Lymph Nodes</term><term>Lymphatic Vessels</term><term>Lymphedema</term><term>Myocardium</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Humans</term><term>Intestinal Absorption</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Absorption intestinale</term><term>Animaux</term><term>Humains</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The lymphatic vascular system has an important role in the maintenance of tissue fluid pressure homeostasis, in the mediation of the afferent immune response via recruitment of antigen-presenting cells toward draining lymph nodes, and in the intestinal absorption of dietary lipids. Substantial progress in our understanding of the development and the molecular mechanisms controlling the lymphatic system has been made during the last few years, based on a recent wave of discoveries of lymphatic endothelial cell-specific markers and growth factors. This has also led to new insights into the role of lymphatic endothelium in a number of diseases, including primary and secondary lymphedemas. The emerging role of lymphatic endothelium in the context of inflammation indicates that therapeutics targeting the lymphatic vasculature might represent a new strategy for anti-inflammatory therapies.</div></front></TEI><affiliations><list><country><li>Suisse</li></country></list><tree><noCountry><name sortKey="Detmar, Michael" sort="Detmar, Michael" uniqKey="Detmar M" first="Michael" last="Detmar">Michael Detmar</name></noCountry><country name="Suisse"><noRegion><name sortKey="Jurisic, Giorgia" sort="Jurisic, Giorgia" uniqKey="Jurisic G" first="Giorgia" last="Jurisic">Giorgia Jurisic</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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